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The entire coding region of exon 1 and part of the coding
region of exon 2 were replaced with a pGKneo cassette via
homologous recombination. RT-PCR demonstrated lack of mRNA
in homozygous mutant pituitary glands.
GHSR null mice have improved insulin sensitivity
Genomics - Modifications
Texas A & M University System Health Science Center
Curation Flag Information
New comment to be added:
Hyperinsulinemic-Euglycemic Clamp Order #1460 1/10/08
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues.
Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y
, 2011 (10), 996 - 1010
Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice.
Ma X, Lin Y, Lin L, Qin G, Pereira FA, Haymond MW, Butte NF, Sun Y
American journal of physiology. Endocrinology and metabolism
, 2012 (303), E422 - E431
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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