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Strain
C57BL/6-Zbtb16tm1Ppp

Summary Data Summary
Official Name C57BL/6-Zbtb16tm1Ppp
Common Name C57BL/6-PLZFtm1Ina
Description A 3.5 kb genomic fragment containing the 5' coding region
was replaced with a neomycin resistance cassette. Western
blot analysis on extracts from homozygous mice confirmed
that no detectable protein was made from this allele.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
Phenotype Description Homozygous mutants exhibit abnormal anterior-posterior
patterning, with skeletal abnormalities of the limb,
especially the hindlimb, and homeotic transformations of
anterior skeletal elements into posterior structures. Males
develop infertility due to loss of germline cells with age.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Tad InagamiVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Zbtb16knockoutknockoutNot Specified


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