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A 3.5 kb genomic fragment containing the 5' coding region
was replaced with a neomycin resistance cassette. Western
blot analysis on extracts from homozygous mice confirmed
that no detectable protein was made from this allele.
Homozygous mutants exhibit abnormal anterior-posterior
patterning, with skeletal abnormalities of the limb,
especially the hindlimb, and homeotic transformations of
anterior skeletal elements into posterior structures. Males
develop infertility due to loss of germline cells with age.
Genomics - Modifications
Curation Flag Information
New comment to be added:
Oxymax Energy Expenditure Order #2172 2/3/11
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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