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Experiment

Effect of antibiotics on energy expenditure in A/J and C57BL/6J mice fed a low-
or high-fat diet.
Summary Data Summary
Investigator Knotts, Trina
Description In this study, the effect of antibiotic treatments on obesity and glucose
homeostasis will be determined. Mice were maintained on high fat, high energy
diets in two different mouse strains--one obesity-prone (C57Bl/6J) and one
obesity-resistant (A/J). C57Bl/6J and A/J mice were put on semi-purified low
(10%) or high fat (60%) HF diet (Research Diets, D12450J and D12492,
respectively) for 8 weeks. Mice were then provided the antibiotic regimen (water
or cefaperazone) in their drinking water for 4 weeks. Body composition was
assessed by ECHO MRI and energy expenditure and activity by indirect respiratory
calorimetry.

Applicable research area(s): Diabetes, Metabolism, Obesity
Status Completed
Public Release 8/30/2021
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals71
Experimental Conditions6
Catalog Items3
Curation Info (# flags)1
Phenotype Assays27
Phenotype Measurements1917
Histology Images0
Publications0
Phenotypes17


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
36
0
A/J
0
35
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Cefaperazone
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 Drinking Water
The drug was delivered in the drinking water.

Experimental Factor: Drug Dose Units

 g/L
grams per liter

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Research Diets - D12450J
Rodent Diet with 10% fat, 70% carbohydrate, 20% protein
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0001260increased body weight
greater than normal average weight [J:33400]
MMPC Search Results
MP:0001262decreased body weight
lower than normal average weight [PMID:10709991]
MMPC Search Results
MP:0001402hypoactivity
general reduced locomotor activity; reduced movement from one place to another or having a decreased state of activity [ISBN:0-683-40008-8| MGI:csmith]
MMPC Search Results
MP:0003960increased lean body mass
greater amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue [MGI:csmith]
MMPC Search Results
MP:0003961decreased lean body mass
reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue [MGI:csmith]
MMPC Search Results
MP:0005202lethargy
mild impairment of consciousness resulting in reduced alertness and awareness and/or sluggish behavior or inactivity; can be due to generalized brain dysfunction [ISBN:0-683-40008-8]
MMPC Search Results
MP:0005290decreased oxygen consumption
less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body [MESH:G06.535.723]
MMPC Search Results
MP:0008964decreased carbon dioxide production
reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas [MGI:csmith]
MMPC Search Results
MP:0010025decreased total body fat amount
less than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]
MMPC Search Results
MP:0010378increased respiratory quotient
increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls [MGI:csmith]
MMPC Search Results
MP:0010379decreased respiratory quotient
reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls [MGI:csmith]
MMPC Search Results
MP:0011939increased food intake
increase in the total number of calories/food amount taken in over time when compared to the normal state [MGI:csmith]
MMPC Search Results
MP:0011940decreased food intake
reduction in the total number of calories/food amount taken in over time when compared to the normal state [MGI:csmith]
MMPC Search Results
MP:0011945increased eating frequency
increase in the number of discrete instances of initiation of eating over time| regardless of amount eaten [MGI:csmith]
MMPC Search Results
MP:0012344decreased gnawing activity
decreased biting or chewing on something [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results
MP:0014143decreased body fat mass
decreased physical bulk or volume of fat in the whole body [MGI:csmith]
MMPC Search Results
MP:0020211slow movement
decreased rate or speed of the coordinated movements executed with a purpose [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results

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