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Experiment

Effect of sEH inhibitor in alcohol induced liver injury model on gut
permeability in control compared to liver-specific sEH knockouts
Summary Data Summary
Investigator Mello, Aline
Description Mice (control floxed mice or liver-specific soluble epoxide hydrolase knockouts)
were fed 5 days of control Lieber DeCarli liquid diet for acclimation, followed
by 10 days of alcohol Lieber DeCarli liquid diet supplemented with 5% ethanol or
pair-fed control Lieber DeCarli liquid diet with or without treatment with sEH
inhibitor for 10 days (same time as the alcohol diet was initiated) or 5 days (5
days into the 10 day alcohol diet).
Status Completed
Public Release 3/1/2021
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals8
Experimental Conditions9
Catalog Items2
Curation Info (# flags)2
Phenotype Assays2
Phenotype Measurements32
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
sEH flox, Alb-cre, AlbCre,
0
3
0
sEH flox
0
5
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 No Drug/Treatment
No Drug or Treatment done on these samples
 TPPU
TPPU (N-[1-(1-oxopropyl)-4-piperidinyl]-N-[4-(trifluoromethoxy)phenyl)-urea) is a potent inhibitor of both human and mouse sEH.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 Diet
The drug was delivered via food.

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 BioServ F1258SP
Rodent Liquid Diet, Lieber-DeCarli'82, Shake and Pour, Ethanol. Protein 151 kcal/Liter, Fat 135 kcal/Liter, Carbohydrate 1000 kcal/Liter, Ethanol 355 kcal/Liter

Experimental Factor: Tissue Source

 colon
colon
 ileum
ileum



No documents found.

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