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Experiment

Influence of Myo KO mutation on metabolic phenotype and energy balance
Summary Data Summary
Investigator Adams, Sean
Description The objective of this study is to determine if knocking out myoglobin influences
substrate oxidation (respiratory exchange ratio) and other metabolic phenotypes
in high-fat fed, cold-challenged mice.

Male & female MyoKO and litter mate controls will have their baseline energy
expenditure assessed by CLAMS at 5 weeks of age. Animals will be placed on
high-fat (HFD) diet at 6 weeks After 5 weeks on diet (age= 11 w) and 12 weeks on
diet (age=17 w) energy expenditure will be reassessed. Energy expenditure will
be assesses at 10 and 22°C followed by body composition analysis by DEXA.
Status Completed
Public Release 5/16/2021
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagAnimal Count
Data Analysis
TypeCount
Animals39
Experimental Conditions4
Catalog Items7
Curation Info (# flags)1
Phenotype Assays31
Phenotype Measurements7254
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6N +/+
10
10
0
Mb KO
9
10
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Teklad - 08511
45% Fat Kcal Diet (ISP) -- The mid-fat diet in a series of diets with isolated soy protein, 10, 45, or 60% kcal from fat, with ~43% of the total carbohydrate from sucrose, and equivalent vitamin and mineral levels adjusted on an energy basis....
 Teklad - 2918
Harlan-Teklad 2918 (Irradiated) 18.6% protein (Calories : 24% protein, 18% Fat, 58% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast,...



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