University of California Davis
University of Cincinnati Medical Center
University of Massachusetts Medical School
University of Michigan Medical School
Vanderbilt University School of Medicine
Protocols & Methods
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Tracers in Metabolic Research
Isotope Tracers in Metabolic Research: 3-Part Webinar Series
Energy Expenditure Analysis
CalR: Indirect Calorimetry Analysis
Guidelines & Policies
New comment to be added:
Effects of Ryanadine receptor hemizygosity on energy expenditure with running
Mutations in Either type 1 receptor (RyR1) or the dihydropyridine
receptorsubunit Cav1.1 cause malignant hyperthermia susceptiblity (MHS) in
humans and animals. It is necessary to understand how altered RyR1 channel
regulation influences baal changes in mitochondrial bioenergetics, produces
oxidative stress and promotes progressive muscle change. This study is a
follow-up study to the running wheel study done in male and female mice (WT and
HET). Here, energy expenditure (by indirect calorimetry) and core temperature
readings are assessed while allowed access to voluntary running wheels at two
environmental temperatures (22 and 28 C). This will allow us to better
characterize how ambient temperature influences heat stress in MHS mice females
when compared to males.
Applicable research area(s): Metabolism
week(s) post-natal (w)
DOWNLOAD ALL DATA (.csv)
Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.
Experimental Factor: Light-Dark Period
The Dark period
The light period
Experimental Factor (Units)
Environmental Temperature (°C) (°C)
Wheel Running (day)
Add / Edit
energy intake (24 hr)
energy intake (24 hr)
oxygen consumption (Light Period)
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
bone mineral density
bone mineral content
fat tissue, %
% body fat
heat (Light Period)
oxygen consumption (Dark Period)
carbon dioxide production Light Period
carbon dioxide production Dark Period
respiratory exchange ratio (Dark Period)
heat (Dark Period)
carbon dioxide production
respiratory exchange ratio
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
total tissue mass
heat - 24h
Bout Distance, Average
Avg Bout Distance
Bout Time, Average
Avg Bout Time
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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