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Experiment

Hyperinsulinemic Clamp Order #1470 2/26/08
Summary Data Summary
Investigator Kuo, Calvin
Description Neutralization of VEGF signaling via soluble VEGF receptor in adult animals
reveals previously unsuspected role of VEGF and the vascular endothelium in
modulating glucose metabolism. Characterizing the physiological effects of VEGF
inhibitors on glucose metabolism provides insight into the regulation of
metabolism by VEGF signaling and explores the therapeutic potential of VEGF
inhibitors in controlling hyperglycemia in pathological settings such as type II
DM.

in C57BL/6J or CB17/SCID mice:
lower blood glucose level (fed and fasting)
improved glucose tolerance (IPGTT)
lower serum insulin level
suppression of hepatic g6pc and pepck

in Lepr db/db mice:
lower blood glucose level (fed and fasting)
improved glucose tolerance (IPGTT)
lower serum insulin level

Applicable research area(s): Diabetes, Metabolism, Cardiovascular
Status Completed
Public Release 6/17/2011
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals16
Experimental Conditions5
Catalog Items1
Curation Info (# flags)2
Phenotype Assays16
Phenotype Measurements3816
Histology Images0
Publications0
Phenotypes2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
16
0
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Saline
Saline
 VEGF-Trap
VEGF blocker

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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