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Experiment

Understanding the effects of prebiotic 2-Fucosyl-Lactose on gut permeability and
plasma LBP
Summary Data Summary
Investigator Mills, David
Description Mice were treated (orally/gavage) for the initial 5 days +/- Bifidobacterium)
and given water or water + 2'fucosyl-lactose (2'FL) in their drinking water for
the entire 15 day duration of the experiment. Mice were then challenged with
either saline or LPS (0.1mg/kg IP) for the final 5 days of the experimental
paradigm.

Applicable research area(s): Metabolism, Obesity
Status Completed
Public Release 11/30/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals36
Experimental Conditions10
Catalog Items2
Curation Info (# flags)1
Phenotype Assays3
Phenotype Measurements216
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
36
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Bacteria Delivery Route

 Gavage
Gavage refers to supplying a substance by means of a small plastic feeding tube passed through the nose (nasogastric) or mouth (orogastric) into the stomach.

Experimental Factor: Bacteria Dose Units

 CFU
Colony Forming Units

Experimental Factor: Bacteria Introduced

 Bifidobacterium infantis
Bifidobacterium longum subspecies infantis Bifidobacterium is a genus of gram-positive, nonmotile, often branched anaerobic bacteria. They are ubiquitous inhabitants of the gastrointestinal tract, vagina and mouth (B. dentium) of mammals,...

Experimental Factor: Drug Administered

 2-Fucosyllactose
2'-Fucosyllactose is an oligosaccharide. It is the most prevalent human milk oligosaccharide (HMO), making up about 30% of all of HMOs.
 LPS
Lipopolysaccharide - induces bacterial infection
 Saline
Saline
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 Drinking Water
The drug was delivered in the drinking water.
 IP
The drug was delivered intraperitoneal.

Experimental Factor: Drug Dose Units

 %
% of drug in vehicle
 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Tissue Source

 colon
colon
 ileum
ileum



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