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New comment to be added:
Examine effect of maternal DDT exposure on energy expenditure in
temperature-challenged female mice.
La Merrill, Michele
While less of a problem in the USA, exposure to the pesticide
4,4'-dichlorodiphenyltrichloroethane (DDT) due to environmental contamination
and in regions where DDT continues to be used extensively for malaria control,
or were born prior to its ban elsewhere is still a major health concern. The
goal of this study is to understand the possible contribution of DDT to
Female C57BL/6J mice (15) whose mothers were treated with either Vehicle (oil)
or DDT (1.7mg/kg, po,14 days) had their energy expenditure assessed by high
resolution indirect calorimetry while subjected to a range of environmental
temperatures (12, 18, 24, 28, 30, 32, 34 and 36°C) as well as core body
temperature measured by IP implanted temperature recorder.
Applicable research area(s): Diabetes, Obesity, Metabolism
week(s) post-natal (w)
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Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Drug Experimental Group
Mother injected with DDT
The mother of this animal was injected with DDT
Mother injected with Oil
The mother of this animal was injected with oil
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Drug Experimental Group
Environmental Temperature (°C) (°C)
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fat body mass
fat body mass
lean body mass
lean body mass
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bone mineral content
fat tissue, %
% body fat
total tissue mass
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