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New comment to be added:
Effect of Maternal DDT exposure on baseline energy expenditure
La Merrill, Michele
While less of a problem in the USA, exposure to the pesticide
4,4'-dichlorodiphenyltrichloroethane (DDT) due to environmental contamination
and in regions where DDT continues to be used extensively for malaria control,
or were born prior to its ban elsewhere is still a major health concern. The
goal of this study is to understand the possible contribution of DDT to
Female C57BL/6J mice whose mothers were treated with either Vehicle (oil) or DDT
(1.7mg/kg, po, 14 days) were assessed for baseline energy expenditure by
indirect calorimetry, body composition by DEXA, and core body temperature
measured by IP implanted temperature recorder.
Applicable research area(s): Diabetes, Obesity, Metabolism
week(s) post-natal (w)
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Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Drug Experimental Group
Mother injected with DDT
The mother of this animal was injected with DDT
Mother injected with Oil
The mother of this animal was injected with oil
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Drug Experimental Group
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oxygen consumption (Light Period)
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
bone mineral density
bone mineral content
fat tissue, %
% body fat
heat (Light Period)
oxygen consumption (Dark Period)
carbon dioxide production Light Period
carbon dioxide production Dark Period
respiratory exchange ratio (Dark Period)
heat (Dark Period)
carbon dioxide production
respiratory exchange ratio
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (avg 24 hr)
energy intake avg 24
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
total tissue mass
heat - 24h
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Mammalian Phenotype (MP) Terms
decreased bone mineral content
reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area [MGI:csmith]
MMPC Search Results
decreased subchondral bone mineral content
decreased amount (usually in grams/cm) of bone mineral divided by a bone-scanned area in the bone region of the epiphysis that provides underlying mechanical and physiological support for the cartilage of joint articular surfaces [MGI:csmith| PMID:20392241]
MMPC Search Results
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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