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Experiment

Hyperinsulinemi clamp order #22012 December 2016
Summary Data Summary
Investigator Williams, Ashley
Description Obesity and diabetes are associated with decreased skeletal muscle activity of
carnitine acetyltransferase (CrAT), an enzyme that regulates energy metabolism.
CrAT insufficiency in the skeletal muscle contributes to metabolic dysfunction.
The objective of this research is to determine whether the deletion of CrAT in
the muscle impairs the ability of the muscle to respond to insulin. Results from
this study will enhance our understanding of muscle metabolism, and to identify
potential therapeutic strategies for restoring CrAT function in the context of
aging and disease.

Applicable research area(s): Diabetes, Obesity, Metabolism
Status Completed
Public Release 4/6/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagAnimal Count
Data Analysis
TypeCount
Animals24
Experimental Conditions5
Catalog Items4
Curation Info (# flags)1
Phenotype Assays20
Phenotype Measurements6792
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J-Crattm1.1Pbrc Tg(Ckmm-cre)5Khn
0
12
0
C57BL/6J-Cratlox/lox
0
12
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Research Diets - D03021303i
High-fat diet with additional sucrose: 45 kcal% Fat and 25 kcal% Sucrose Special notes: Diet is irradiated with 10-20 kGy gamma-irradiation.



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