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Experiment

Intestinal permeability in obese and lean mice following acute radiation
exposure
Summary Data Summary
Investigator Murphy, William
Description Radiosensitivity of lean and obese mice to acute radiation exposure. Obesity
environment produces high level of pro-inflammatory cytokines which could
exacerbate effects of radiation exposure. We hypothesize that GI tract and liver
would be the main target tissues for inflammation post-radiation. Male
C57BL/6NTac were fed either 10% LFD (D12450J) or 60% HFD (D12492) for 4 months.
Animals on both diets were divided into 3 groups : control and 2 doses of X-ray
(TBI 800 cGy and 1050 cGy); mice were euthanized and tissues obtained on day 3
post-radiation.

Applicable research area(s): Obesity
Status Completed
Public Release 3/8/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals18
Experimental Conditions6
Catalog Items2
Curation Info (# flags)2
Phenotype Assays2
Phenotype Measurements48
Histology Images0
Publications0
Documents1


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6NTac
0
18
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Research Diet - D12450J
Rodent Diet with 10% kcal% fat. The fat comes from Lard and Soybean Oil
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat

Experimental Factor: Radiation Type

 X-ray
Used X-rays as the radiation type for the experiment.

Experimental Factor: Tissue Source

 colon
colon
 ileum
ileum



No documents found.

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