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Experiment

Assessment of RyR1 mutant mouse activity
Summary Data Summary
Investigator Pessah, Isaac
Description Mutations in Either type 1 receptor (RyR1) or the dihydropyridine receptors
subunit Cav1.1 cause malignant hyperthermia susceptibility (MHS) in humans and
animals. It is necessary to understand how altered RyR1 channel
regulation influences activity at standard vivarium temperatures (22C)and closer
to thermal neutral zone temperatures (26, 28, and 30C). Animal number 653 was
exuded after the standard vivarium temperature test as it as found to be
pregnant.

Applicable research area(s): Metabolism
Status Completed
Public Release 2/9/2019
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals30
Experimental Conditions4
Catalog Items1
Curation Info (# flags)0
Phenotype Assays3
Phenotype Measurements2925
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
8
8
0
RyR1-R163C
6
8
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.

Experimental Factor: Light-Dark Period

 Dark
The Dark period
 Light
The light period


Phenotype Assays Add / Edit



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